Through the analysis of casting thin sections, 3D geological modeling, special logging series and micro seismic monitoring, reservoir stress characteristics of Jing’an area were studied. The results show that: 1) the distribution of the direction of micro pore and throat would cause the stress anisotropy; 2) differences in each layer of Chang 4+52 sandstone are big, the lateral superposition characteristics of multi-periods channels have the major influence on stress distribution; 3) the stress difference in the study area is generally not large with the value of 3?6 MPa, with the development of water flooding development, the variation of the two main stress varies in the reservoir, resulting in the multi-directional development of fractures in the process of repeated fracturing. The results can provide a scientific basis for improving oil recovery in the middle and late development of low permeability reservoirs.